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Proflavanol (Grape Seed)

Provides a potent antioxidant formula based on a synergistic combination of grape seed bioflavonoids and POLY C® May help maintain capillary strength and vascular function and help maintain healthy immune function
( usana )
RM153.00
RM135.00
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90 Tablets / Bottle
Item #: 133
Supplement Facts
More Information
  • Provides a potent antioxidant formula based on a synergistic combination of grape seed bioflavonoids and POLY C®
  • May help maintain capillary strength and vascular function and help maintain healthy immune function
  • Designed and manufactured according to USP and pharmaceutical GMP guidelines

It is a paradox of life. We require oxygen for efficient energy production and for the function of many metabolic pathways. And yet oxygen, in a variety of chemical forms collectively known as "reactive oxygen species" (ROS), is toxic to our cells and tissues. Elevated exposure to ROS creates a physiological imbalance known as oxidative stress. Dietary antioxidants are a primary line of defence against oxidative stress.


Proflavanol® & Proflavanol® 90

Powerful bioflavonoid supplement

Health Basics

• Clinically proven to promote sound cardiovascular health*

• Helps support balanced immune function*

• Supports eye health*

• Essential for maintaining healthy, younger-looking skin*

Did You Know?

• Grape-seed bioflavonoids and vitamin C work together to provide advanced

antioxidant protection.*

Plants are living pharmacies, producing thousands of

substances that are beneficial to human health. There are

several major categories of these phytonutrients, including

the plant pigments called bioflavonoids. While clearly

exhibiting antioxidant capabilities that offer protection

from oxidative stress, bioflavonoids are probably even

more important for their ability to modulate cell-signaling

pathways. Among the many important cell-signaling

functions that bioflavonoids influence are regulating the

cell cycle, inhibiting cell proliferation, and producing

detoxification enzymes.1-5

Proanthocyanidins

Proanthocyanidins are a subclass of bioflavonoids found in

blue and purple berries, purple grapes, and red wine, and they

are available in relatively high concentrations in grape-seed

extract. Research suggests a strong role for dietary bioflavonoids,

including proanthocyanidins, in supporting and maintaining

sound cardiovascular function.6-8 Epidemiological evidence of this

connection begins with the observation that relatively low rates

of heart disease exist in France, despite a diet high in saturated

fat.9 This apparent “French paradox” has been attributed to the

proanthocyanidins in the red wine consumed with most meals.

Human clinical research has also shown that proanthocyanidins

in red wine maintain healthy endothelial function.10,11*

Proanthocyanidins have been studied extensively in Europe and

in the United States. Scientifically observed and documented

benefits include the following:

• Helps protect plasma LDL from oxidation12*

• Helps retain healthy capillary strength and vascular function13,14*

• Supports healthy immune function15*

• Supports healthy peripheral circulation16*

Why Proflavanol® & Proflavanol® 90?

With USANA’s unique formulation, Proflavanol® and triplestrength

Proflavanol® 90 bioflavonoid supplements combine

the highest quality grape-seed extract with the free-radical

quenching power of exclusive Poly C® (see page 36), giving

you an important tool in the quest for lifelong good health.17,18

Laboratory studies done at USANA confirm that, when used

together, these ingredients provide significantly better protection

against the oxidative modification of low density lipoproteins

(LDL) than would be predicted from the sum of their individual

effects. Not only do proanthocyanidins neutralize free radicals,

they also conserve and regenerate vitamins C and E.19*

References
1. Middleton E, et al. Pharmacol Rev. 2000. 52:673-751.
2. Y oshida M, et al. Cancer Res. 1992. 52:6676-6681.
3. K rinsky N. Proc Soc Exp Biol Med. 1992. 200:248-254.
4. F u Y, et al. Mol Pharmacol 2008 73(5):1465-73.
5. M iddleton E and Kandaswami C Biochem Pharmacol 1992. 43:1167-1179.
6. Dell’Agli M, et al. Cardiovasc Res 2004;63(4):593-602.
7. Folts JD. Adv Exp Med Biol 2002;505:95-111.
8. Cos P, et al. Curr Med Chem 2004;11(10):1345-59.
9. Renaud S, de Lorgeril M, Lancet 1992;339:1523-26.
10. Stoclet JC, et al. J Physiol Pharmacol 1999;50: 535-40.
11. Cuevas AM, et al. Lipids 2000;35:143-48.
12. F uhrman B, et al. Am J Clin Nutr 1995;61:549-54.
13. G azave JM, et al. Biochem Exp Biol 1978;14:25-31.
14. B aruch J. Ann Chir Plast Esthet 1984;29(4).
15. K akegawa , et al. Chem Pharm Bull (Tokyo) 1985;5079-82.
16. B eylot C, Bioulac P. Gaz Med de France 1980;87(22).
17. M affei F, et al. Arzneimittelforschung 1994;44:592-601.
18. W hitehead TP, et al. Clin Chem 1995;41:32-35.
19. Lagrue G, et al. Sem Hop Paris 1981;September:18-25.

Supplement Facts

Serving Size 1 Tablet

Amount per SERVING % DV*

Vitamin C (as Calcium, Potassium, 100 mg 170%

Magnesium and Zinc Ascorbates)

Calcium (as Calcium Ascobates) 6.3mg 1%

Potassium (as Potassium Ascobates) 7.1mg 0%

Magnesium (as Magnesium Ascobates) 1.2mg 0%

Zinc (as Zinc Ascobates) 0.2mg 1%

Grape Seed Extract (VITIS VINIFERA L., SEEDS) 30 mg †

* Percent Daily Values are based on a 2,000 calorie diet.

† Daily Value not established.

Directions: Take Two tablets daily, PREFERABLY WITH MEALs.

Other Ingredients: Microcrystalline Cellulose, croscarmellose sodium, Pregelatinized

Starch, ASCORBYL PALMITATE, DEXTRIN, SILICON DIOXIDE , DEXTROSE, SOY LECITHIN, Sodium Citrate.

laboratory tested, quality guaranteed. meets usp specifications

for potency, uniformity, and disintegration, where applicable.








 

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